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Is it possible for a change of a single nucleotide in DNA to have
an observable effect on phenotype?

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Answer:

No change occurs in phenotype.

Some mutations don't have any noticeable effect on the phenotype of an organism.

It's visible for the single strand of DNA to undergo changes then the phenotype will show no change.

What is DNA and what's the observable affect of phenotype.?

As the DNA is a genetic material that makes up the proteins and refers to the two strands of the molecular acid that is consists of the polynucleotide chain. It has functions that relate to the development, functioning, growth of the organism.

As some mutations don't occur or show any noticeable effect on the phenotype of an organism. As phenotypes the visible character of the organism and related to the interaction between the genotype and the envirnment. Thus not all mutation will take place directly that can be observed in the phenotype.

Find out more information about the change of a single nucleotide.

brainly.com/question/15802667.