A. True. Summing any rational number with an irrational number leads to an irrational result. The proof is a bit lengthy so I'm leaving it out.
B. True. Adding p/q with r/s leads to (ps+qr)/(qs) which is rational. Keep in mind that q and s cannot be zero.
C. False. One counter example is sqrt(3)*sqrt(12) = sqrt(3*12) = sqrt(36) = 6. This shows the product of two irrational numbers, in this case sqrt(3) and sqrt(12), multiplying to get a rational result 6 = 6/1.
D. True. Multiplying p/q and r/s leads to (p*r)/(q*s) which is rational. Keep in mind that q and s cannot be zero.
----------------------------------------------------------------------
The final answer is choice C